@article {5435,
	title = {Minute-scale periodicity of neuronal firing in the human entorhinal cortex},
	journal = {Cell Reports},
	volume = {42},
	year = {2023},
	month = {11/2023},
	pages = {113271},
	abstract = {<p>Grid cells in the entorhinal cortex demonstrate spatially periodic firing, thought to provide a spatial map on behaviorally relevant length scales. Whether such periodicity exists for behaviorally relevant time scales in the human brain remains unclear. We investigate neuronal firing during a temporally continuous experience by presenting 14 neurosurgical patients with a video while recording neuronal activity from multiple brain regions. We report on neurons that modulate their activity in a periodic manner across different time scales{\textemdash}from seconds to many minutes, most prevalently in the entorhinal cortex. These neurons remap their dominant periodicity to shorter time scales during a subsequent recognition memory task. When the video is presented at two different speeds, a significant percentage of these temporally periodic cells (TPCs) maintain their time scales, suggesting a degree of invariance. The TPCs{\textquoteright} temporal periodicity might complement the spatial periodicity of grid cells and together provide scalable spatiotemporal metrics for human experience.</p>
},
	issn = {22111247},
	doi = {10.1016/j.celrep.2023.113271},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2211124723012834},
	author = {M. Aghajan, Zahra and Kreiman, Gabriel and Fried, Itzhak}
}
