@article {5511, title = {Dissociable neuronal substrates of visual feature attention and working memory}, journal = {Neuron}, volume = {112}, year = {2024}, month = {01/2024}, pages = {850 - 863.e6}, abstract = {

Attention and working memory (WM) are distinct cognitive functions, yet given their close interactions, it is often assumed that they share the same neuronal mechanisms. We show that in macaques performing a WM-guided feature attention task, the activity of most neurons in areas middle temporal (MT), medial superior temporal (MST), lateral intraparietal (LIP), and posterior lateral prefrontal cortex (LPFC-p) displays attentional modulation or WM coding and not both. One area thought to play a role in both functions is LPFC-p. To test this, we optogenetically inactivated LPFC-p bilaterally during different task periods. Attention period inactivation reduced attentional modulation in LPFC-p, MST, and LIP neurons and impaired task performance. In contrast, WM period inactivation did not affect attentional modulation or performance and minimally affected WM coding. Our results suggest that feature attention and WM have dissociable neuronal substrates and that LPFC-p plays a critical role in feature attention, but not in WM.

}, issn = {08966273}, doi = {10.1016/j.neuron.2023.12.007}, url = {https://linkinghub.elsevier.com/retrieve/pii/S0896627323009352}, author = {Diego Mendoza-Halliday and Xu, Haoran and Azevedo, Frederico A.C. and Desimone, Robert} } @article {5512, title = {A ubiquitous spectrolaminar motif of local field potential power across the primate cortexAbstract}, journal = {Nature Neuroscience}, volume = {27}, year = {2024}, month = {01/2024}, pages = {547 - 560}, abstract = {

The mammalian cerebral cortex is anatomically organized into a six-layer
motif. It is currently unknown whether a corresponding laminar motif of
neuronal activity patterns exists across the cortex. Here we report such a
motif in the power of local field potentials (LFPs). Using laminar probes,
we recorded LFPs from 14 cortical areas across the cortical hierarchy in five
macaque monkeys. The laminar locations of recordings were histologically
identified by electrolytic lesions. Across all areas, we found a ubiquitous
spectrolaminar pattern characterized by an increasing deep-to-superficial
layer gradient of high-frequency power peaking in layers 2/3 and an
increasing superficial-to-deep gradient of alpha-beta power peaking in
layers 5/6. Laminar recordings from additional species showed that the
spectrolaminar pattern is highly preserved among primates{\textemdash}macaque,
marmoset and human{\textemdash}but more dissimilar in mouse. Our results suggest
the existence of a canonical layer-based and frequency-based mechanism
for cortical computation.

}, issn = {1097-6256}, doi = {10.1038/s41593-023-01554-7}, url = {https://www.nature.com/articles/s41593-023-01554-7}, author = {Diego Mendoza-Halliday and Major, Alex James and Lee, Noah and Lichtenfeld, Maxwell J. and Carlson, Brock and Mitchell, Blake and Meng, Patrick D. and Xiong, Yihan and Westerberg, Jacob A. and Jia, Xiaoxuan and Johnston, Kevin D. and Selvanayagam, Janahan and Everling, Stefan and Maier, Alexander and Desimone, Robert and Miller, Earl K. and Bastos, Andr{\'e} M.} }