@article {1759,
	title = {Canonical genetic signatures of the adult human brain},
	journal = {Nature Neuroscience},
	volume = {18},
	year = {2015},
	pages = {1844},
	chapter = {1832},
	abstract = {<div>The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structures in six individual brains, revealing mesoscale genetic organization. The genes with the highest differential stability are highly biologically relevant, with enrichment for brain-related annotations, disease associations, drug targets and literature citations. Using genes with high differential stability, we identified 32 anatomically diverse and reproducible gene expression signatures, which represent distinct cell types, intracellular components and/or associations with neurodevelopmental and neurodegenerative disorders. Genes in neuron-associated compared to non-neuronal networks showed higher preservation between human and mouse; however, many diversely patterned genes displayed marked shifts in regulation between species. Finally, highly consistent transcriptional architecture in neocortex is correlated with resting state functional connectivity, suggesting a link between conserved gene expression and functionally relevant circuitry</div>
},
	author = {Michael Hawrylycz and Jeremy A Miller and Vilas Menon and David Feng and Tim Dolbeare and Angela L Guillozet-Bongaarts and Anil G Jegga and Bruce J Aronow and Chang-Kyu Lee and Amy Bernard and Matthew F Glasser and Donna L Dierker and J{\"o}rge Menche and Aaron Szafer and Forrest Collman and Pascal Grange and Kenneth A Berman and Stefan Mihalas and Zizhen Yao and Lance Stewart and Albert-L{\'a}szl{\'o} Barab{\'a}si and Jay Schulkin and John Phillips and Lydia Ng and Chinh Dang and David R Haynor and Allan Jones and David C Van Essen and Christof Koch and Ed Lein}
}
