%0 Journal Article %J Trends in Neurosciences %D 2017 %T Sustained Activity Encoding Working Memories: Not Fully Distributed %A Leavitt, M.L. %A Diego Mendoza-Halliday %A Martinez-Trujillo J.C. %K working memory sustained activity neurophysiology fMRI primate review %X

Working memory (WM) is the ability to remember and manipulate information for short time intervals. Recent studies have proposed that sustained firing encoding the contents of WM is ubiquitous across cortical neurons. We review here the collective evidence supporting this claim. A variety of studies report that neurons in prefrontal, parietal, and inferotemporal association cortices show robust sustained activity encoding the location and features of memoranda during WM tasks. However, reports of WM-related sustained activity in early sensory areas are rare, and typically lack stimulus specificity. We propose that robust sustained activity that can support WM coding arises as a property of association cortices downstream from the early stages of sensory processing.

%B Trends in Neurosciences %V 40 %P 328-346 %8 June 2017 %G eng %U https://www.sciencedirect.com/science/article/pii/S0166223617300711 %N 6 %R https://doi.org/10.1016/j.tins.2017.04.004