Powell, Kosakowski, and Saxe [1] argued in a recent review that two bottom-up models previously proposed to account for the development of face domains in inferotemporal cortex (IT) 2, 3 are insufficient to explain the existing data. They proposed instead that face domains are predisposed to process faces via selective connectivity to social information in medial prefrontal cortex. Here we explain why activity-dependent mechanisms acting on a retinotopic proto-architecture provide a sufficient explanation for the development of face, and other category, domains...