Hippocampal Remapping as Hidden State Inference

TitleHippocampal Remapping as Hidden State Inference
Publication TypeCBMM Memos
Year of Publication2019
AuthorsSanders, H, Wilson, MA, Gershman, SJ
Date Published08/2019
Abstract

Cells in the hippocampus tuned to spatial location (place cells) typically change their tuning when an animal changes context, a phenomenon known as remapping. A fundamental challenge to understanding remapping is the fact that what counts as a “context change” has never been precisely defined. Furthermore, different remapping phenomena have been classified on the basis of how much the tuning changes after different types and degrees of context change, but the relationship between these variables is not clear. We address these ambiguities by formalizing remapping in terms of hidden state inference. According to this view, remapping does not directly reflect objective, observable properties of the environment, but rather subjective beliefs about the hidden state of the environment. We show how the hidden state framework can resolve a number of puzzles about the nature of remapping.

DOI10.1101/743260
arXiv

https://www.biorxiv.org/content/10.1101/743260v1

DSpace@MIT

https://hdl.handle.net/1721.1/122040

Download:  PDF icon CBMM-Memo-101.pdf
CBMM Memo No:  101

Associated Module: 

CBMM Relationship: 

  • CBMM Funded